Multiomics

Multiomics

About project

Collaboration and Project Goals

The project is based on close cooperation between research organizations and the application sector. The partnership consists of five research entities – three academic institutions (Charles University, IMIC, IBIT) and two application partners (AffiPro and GeneSpector).

Main objectives and benefits of the project:

  • Systematic interconnection and development of the research and application potential of participating groups and organizations
  • Building long-term partnerships with the application sector
  • Identifying biological correlates of diseases and developing new diagnostic, preventive, and therapeutic approaches
  • Developing and implementing innovative methods in bioinformatics and multi-omics analyses (DNA, RNA, proteins, metabolites)
  • Establishing a functionally complementary platform of multi-omics technologies
  • Creating new diagnostic and therapeutic procedures

Project duration

January 1, 2025 – December 31, 2028 (sustainability until December 31, 2032)

Main recipient

Charles University

Project lead

Prof. Ing. Stanislav Kmoch, CSc.

Multi-omics platform for identifying biological correlates of diseases and developing new diagnostic, preventive, and therapeutic approaches (MULTIOMICS_CZ)

Registration number: CZ.02.01.01/00/23_020/0008540

Identification code: EH23_020/0008540

The project is funded by the Programme Johannes Amos Comenius, Call No. 02_23_020 – Intersectoral Cooperation.

Project Description

  • Establishment of a multi-omics technology platform at BIOCEV to accelerate research on genetic and biological correlates of disease.
  • Connection of teams and infrastructure across partners to standardize and scale analyses of DNA, RNA, proteins, and metabolites.
  • Integration of multi-omics data using advanced bioinformatics.
  • Translation of results into healthcare applications supported by shared protocols and quality assurance.
  • Access to instrumentation and expertise.
  • Fostering of staff development and training opportunities.
  • Pilot studies with application-sector partners to ensure reproducibility, comparability, and validation of findings.

Project Impact

  • Creation of an environment that enables, connects, and develops research and application potential across institutions.
  • Long-term partnerships and cooperation with the application sphere subjects.
  • More robust discovery of disease correlates and mechanisms.
  • Acceleration of diagnostic, preventive, and therapeutic development.
  • Improved readiness for clinical translation of research outputs.
  • Reduction of duplication and higher data quality through shared platforms and governance.
  • Shortened timelines from concept to pilot implementation.
  • Expanded access to advanced technologies across partners.
  • Support for talent development and staff training.
  • Stimulation of follow-on collaborations and funding.
  • Positioning of the consortium as a national hub for multi-omics innovation with healthcare relevance.

Project Objectives

  • Strengthen cooperation between research organizations and the application sector.
  • Build a comprehensive multi-omics platform at BIOCEV.
  • Connect and develop participating groups for collaboration.
  • Standardize sample handling and analytical workflows across partners.
  • Implementation of innovative bioinformatics for integrative analysis across omics layers.
  • Establish a shared portfolio of validated methods, benchmarking datasets, and training modules.
  • Formalize partnerships beyond the core consortium to co-develop use cases and verify clinical/pre-clinical utility.
  • Define responsibilities, data sharing, and routes to joint development through collaboration agreements.