De novo heterozygous variants in EHMT2 genocopy Kleefstra syndrome via loss of G9a methyltransferase activity

by admin | Oct 16, 2025 | Publications

Unpublished preprint Hnízda A, Martinez-Delgado B, Sanchez-Ponce D, et al (2025) bioRxiv 2025.09.25.678439. https://doi.org/10.1101/2025.09.25.678439

Preparation and characterization of flow reactors for the validation of biological drugs

by admin | Oct 16, 2025 | Publications

Diploma thesis Kordík J (2025) Univerzita Karlova, Přírodovědecká fakulta Katedra biochemie, 2025.

Single-nucleus transcriptome analysis provides new insights into B chromosome elimination in sorghum

by admin | Oct 7, 2025 | News

B chromosomes (Bs) are supernumerary entities found in many plant species, with some exhibiting tissue-specific elimination. In Sorghum purpureosericeum, extensive level of the B chromosome elimination occurs during embryogenesis. It progresses quickly and affects...

De novo heterozygous variants in EHMT2 genocopy Kleefstra syndrome via loss of G9a methyltransferase activity

by admin | Sep 25, 2025 | News

EHMT1 and EHMT2 genes encode human euchromatin histone lysine methyltransferase 1 and 2 (EHMT1 alias GLP; EHMT2 alias G9a) that form heteromeric GLP/G9a complexes with essential roles in epigenetic regulation of gene expression. While EHMT1 haploinsufficiency was...

Novel structure motif for the selective inhibition of TET1 protein based on perimidines

by admin | Aug 20, 2025 | News

The targeting of epigenetic factors, particularly TET proteins (ten-eleven translocation methylcytosine dioxygenases), has emerged as a significant focus in medicinal and biological research. Recent findings indicate that iron chelators possess substantial potential...