The targeting of epigenetic factors, particularly TET proteins (ten-eleven translocation methylcytosine dioxygenases), has emerged as a significant focus in medicinal and biological research. Recent findings indicate that iron chelators possess substantial potential for inhibiting TET activity. In this study, we synthesized two 2-(hetero)aryl-1H-perimidines (perimidine 1 and 2) with iron(II) binding properties…
Source: https://www.sciencedirect.com/science/article/pii/S0022286025023841